WebOct 1, 2016 · Proteomic analysis to characterize the CFTR interactome, including proteins that bind differentially to F508del vs. wild-type CFTR, has suggested hundreds of such binding interactions. Individual roles for many of these CFTR binding partners remains to be determined (7, 8, 57, 90, 112, 122, 137, 158, 187, 203). WebJan 17, 2024 · Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a chloride channel found in secretory epithelia with a plethora of known interacting proteins. Mutations in the CFTR gene cause cystic fibrosis (CF), a disease that leads to progressive respiratory illness and other complications of pheno …
Folding Status Is Determinant over Traffic-Competence in …
WebMar 3, 2004 · Pankow et al. (2015) reported the first comprehensive analysis of the CFTR and delta-F508 CFTR interactome and its dynamics during temperature shift and inhibition of histone deacetylases. By using a novel deep proteomic analysis method, they identified 638 individual high-confidence CFTR interactors and discovered a delta-F508 deletion ... WebAug 16, 2016 · Targeting multiple components of these signalling pathways resulted in potent and specific correction of F508del-CFTR proteostasis and in synergy with pharmacochaperones. These results provide new insights into the physiology of cellular proteostasis and a rational basis for developing effective pharmacological correctors of … ole\u0027s hardware stores california
Therapies for CF May Be Found Using Proteins That Interact With …
WebNov 30, 2015 · Here we report the first comprehensive analysis of the CFTR and ∆F508 CFTR interactome and its dynamics during temperature shift and inhibition of histone … Extended Data Figure 4 Interaction Profiles of Proteins Selected for The RNAi … Extended Data Figure 8 Halide Assay Results for CFTR Chloride Channel … Extended Data Figure 3 Overview of Drug Treatment, siRNA-mediated Knockdown … Extended Data Figure 2 CFTR Interactome and Validation of Novel Interactors - … Extended Data Figure 9 Percentage of CFTR Interactors Associated With … Extended Data Figure 7 ∆F508 CFTR Detection in Primary Bronchial Epithelial … WebNov 17, 2006 · The CFTR interactome predicts that genetic modifiers that affect presentation of CF in the clinic (Cutting, 2005) are now likely to include a number of cellular components, in particular cellular chaperones that either directly or indirectly promote folding for export. We suggest the possibility that the folding capacity defined by Aha1 ... WebFeb 22, 2024 · CFTR is activated by cAMP-dependent phosphorylation at the regulatory (R) domain. Therefore, the CFTR-AKAP (ezrin) ... According to proteomics studies of the mRNA complex (mRNA interactome), ezrin was listed as one of the RNA binding proteins (RBPs) [93,94]. Therefore, ezrin seems to be a component of a messenger ribonucleoprotein. … isaias afwerki education