WebGW9508 is shown to be at least 100-fold selective against 220 other GPCRs, 60 kinases, 63 proteases, seven integrins and 20 nuclear receptors including PPARα, δ and γ (pEC50 4.0, 4 and 4.9, respectively). ... Enter the chemical formula of a compound to calculate its molar mass and elemental composition: Calculate. Total Molecular Weight: g ... WebGW9508 is a free fatty acid receptor agonist able t o protect from ovariectomy-induced bone loss in vivo thought inhibition of osteoclast differentiation i n a G-coupled Protein Receptor 40 (GPR40)-dependent way. In this study, we questioned whether higher doses of GW9508 may also in fluence resorbing cell viability specifically.
GW9508 = 98 HPLC 885101-89-3
WebGW 9508 is a potent and selective agonist for the free fatty acid receptor FFA1 (GPR40) (pEC 50 values are 7.32, < 4.3 and < 4.3 for FFA1, FFA2 and FFA3 receptors respectively). Inactive against a range of other GPCRs, kinases, proteases, integrins and PPARs. Potentiates glucose-stimulated insulin secretion in MIN6 cells (pEC 50 = 6.14). the pizzeria roleplay remastered into the pit
Frontiers Free Fatty Acid Receptor 1 Signaling Contributes to ...
WebApr 7, 2024 · Compound 1 and QS-528 were tested for FFAR1 activation using a Cayman FFAR1 Assay Kit in a single concentration (10 μM). The results obtained are shown in Figure 2. Partial agonist GW9508 was used as a positive ... To determine the FFAR1 activation of compounds 1 and QS-528 «FFAR1 (GPR40) Reporter Assay Kit (Cayman … WebGW9508 is a potent and selective G protein-coupled receptors FFA1 (GPR40) and GPR120 agonist with pEC50s of 7.32 and 5.46, respectively. GW9508 has anti-inflammatory and anti-atherosclerotic activities. ... WebJun 5, 2024 · From the point view of chemical structure, GW9508 involves a phenylpropanoic acid in the molecule, which is vulnerable to glucuronidation to form acyl glucuronide. ... GW9508 was stable in rat plasma at −80 °C for 30 days, 25 °C for 12 h, 10 °C for 8 h in auto-sampler, and after three freeze (−80 °C)-thaw (25 °C) cycles. ... the pizzeria lindenhurst ny