Webb干扰素（IFN）是1957年被发现的。. 它是一类分泌性蛋白，具有广谱抗病毒、抗肿瘤和免疫调节功能。. 根据产生干扰素细胞来源不同、理化性质和生物学活性的差异，可分为α-1b型干扰素、β-干扰素和γ干扰素。. α-1b型干扰素，常用于治疗慢性乙型、丙型和丁型 ... WebbIFN-alpha subtypes are well described (5-9). There are 15 human IFN-alpha subtypes with 80% amino acid identity (10). The number of IFN-alpha subtypes varies by species with 6 equine subtypes, 17 porcine subtypes, 14 bovine subtypes, and 9 canine subtypes known currently. Human IFN-alpha subtypes include: IFN-alpha 1a, IFN-alpha 1b, IFN-alpha ...
Restoration of HBV-specific CD8+ T-cell responses by ... - Nature
IFN-α8 enhances the proliferation of human B cells, as well as being able to activate NK cells. The subtypes α10 and α2, along with α8, are the most efficient and powerful NK cell activators. Subtypes α21 and α2 enhance the expression of IFN-gamma-inducible protein-10 (IP-10) in dendritic cells. Activated dendritic cells initiate immune responses and induce the expression of IP-10, a chemokine which promotes a Th1 inflammatory response. Webb15 jan. 2011 · IFN-α is also shown to be associated with the development of side effects like insomnia, fatigue, alopecia and anorexia [33, 34]. However, further studies on the treatment response and follow up of patients are needed to understand the effectiveness of INF-α against HBV infection in Pakistani population. twist phelan
干扰素家族分类及发展历程_细胞
Webb12 juni 2024 · ifn-α/β二者结合相同受体，分布广泛，包括单核-巨噬细胞、多形核白细胞、b细胞、t细胞、血小板、上皮细胞、内皮细胞与肿瘤细胞等。 2、Ⅱ型干扰素：Ⅱ型干扰素即γ干扰素，主要由活化的T细胞（包括Th0、TH1细胞和几乎所有的CD8+ T细胞）和NK细胞产生，是所谓的淋巴因子（LyTnPhokine）的一种。 WebbDepartment for Disinfection and Infection Control, Chinese PLA Center for Disease Control and Prevention ... bafilomycin A1 was able to significantly down-regulate the release of inflammatory factors in BEAS-2B cells upon A. fumigatus conidia, while rapamycin could reverse the effect of JNK inhibitor on IL-27 and TNF-α release. WebbHematologic adverse events (AEs) were more frequently observed in patients receiving ce-pegalpha-INF-α-2b therapy. Local reactions developed on 3-7 days of therapy as a … twist physical therapy seattle