Sperm associated antigen 6
WebNov 13, 2014 · Sperm associated antigen 6 (SPAG6) is the orthologue of Chlamydomonas PF16. Dysfunction of PF16 gives rise to paralyzed flagella in Chlamydomonas [12] It has been reported that Spag6- deficient mice develop hydrocephalus, and the males are sterile due to sperm motility defects [13] , [14] . WebJul 1, 2015 · Sperm-associated antigen 6 (Spag6) is a Chlamydomonas reinhardtii PF16 homologous gene detected in the human testis and is crucial for sperm motility. Neuronal migration is a dynamic process requiring coordinated cytoskeletal remodeling, and Spag6 is co-localized with microtubules in Chinese hamster ovary cells and COS-1 cells. However, …
Sperm associated antigen 6
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WebSperm-associated antigen 6 (SPAG6) is the mammalian orthologue of Chlamydomonas PF16, an axonemal central pair protein involved in flagellar motility. In mice, two Spag6 … WebIn addition, extracellular sperm- ine and spermidine exhibit anti-inflammatory properties (Soda et al., 2005; Zhang et al., 1997). Inflammation is considered to be a factor accelerating the progression of age-associated pathologies (Franceschi et al., 2000). ... the expression of lymphocyte function-associated antigen-1 (LFA-1) on the surface ...
WebJan 18, 2016 · Virginia Commonwealth University School of Medicine researchers have recently discovered new functions for Sperm Associated Antigen 6 (SPAG6), a gene previously thought to be only important for... WebApr 12, 2024 · The claudin 18.2 (CLDN18.2) antigen is frequently expressed in malignant tumors, including pancreatic ductal adenocarcinoma (PDAC). Although CLDN18.2-targeted CAR-T cells demonstrated some therapeutic efficacy in PDAC patients, further improvement is needed. One of the major obstacles might be the abundant cancer-associated …
WebSep 10, 2024 · Accumulated evidence shows that sperm-associated antigen 6 (SPAG6) gene has multiple biological functions. It maintains the normal function of a variety of cells … WebMammalian SPAG6, the orthologue of Chlamydomonas reinhardtii PF16, is a component of the central apparatus of the '9 + 2' axoneme that controls ciliary/flagellar motility, …
WebDec 20, 2024 · Accumulated evidence shows that sperm-associated antigen 6 (SPAG6) gene has multiple biological functions. It maintains the normal function of a variety of cells including ciliary/flagellar biogenesis and polarization, neurogenesis, and neuronal migration. Moreover, SPAG6 is found to be critically involved in auditory transduction and the ...
WebApr 7, 2006 · Southern blot analysis determined that SPAG6 is highly conserved in primates and that a homolog is present in rodents. Western blot analysis showed that SPAG6 is … dollar tree fourth of july decorWebDec 1, 2024 · The mouse sperm-associated antigen 6 ( Spag6) gene, the orthologue of Chlamydomonas PF16, encodes a 55.3-kDa polypeptide that is a component of the … dollar tree foundersWebsperm-associated antigen 6; Background. The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the ... dollar tree frozen foodsWebOct 21, 2014 · SPAG6, an axoneme central apparatus protein, is essential for function of ependymal cell cilia and sperm flagella. A significant number of Spag6 -deficient mice die … dollar tree fountain valleyWebSep 22, 2024 · Sperm-associated antigen 6 (SPAG6) is an ortholog of chlamydia PF16, located at the chromosomal region 10p12.2 . SPAG6 was originally identified in human testicular tissues and plays a role in regulating germ cell … dollar tree fourth aveWebDec 20, 2024 · The sperm-associated antigen 6 (SPAG6), also known as CT141, repro-sa-1, RP11-301N24.4, and pf16, was identified as a cancer-testis antigen (CTA) and is encoded … dollar tree fridley mnWebMay 12, 2016 · Sperm associated antigen 6 (SPAG6), a component of the central apparatus of the “9 + 2” axoneme, plays a central role in ciliary and flagellar motility; but, its contribution to adaptive immunity... dollar tree fort pierce fl